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Formulation Development Support

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Analysis sample 1: The state of a coating layer in a coated particle

In some pharmaceutical formulations, particles coated with a coating may be used for the purpose of elution control, stabilization, etc. We can investigate the state of the coating layer (thickness, homogeneity, etc.) by internal inspection using CT-X-ray scan. Furthermore, by analyzing the cross section of the coated particle by TOF-SIMS, we can observe how each component is distributed in a coating layer or a core particle.

Analysis sample 2: Raman imaging of a tablet’s surface

Laser Raman microscope enables us to perform imaging of tablet ingredients (active pharmaceutical ingredients, excipients, lubricants, etc.). Raman imaging picture shows us the size and the dispersion state of each ingredient particle.