Foreign Matter Analysis - Eurofins Scientific
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Foreign Matter Analysis

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Analysis example: Identification of foreign matters found in tablets

Identification analysis is conducted on foreign matters (metal-like, fiber-like) found in tablets.

1. Internal inspection of tables by CT-X-ray scan

CT-X-ray scan is used for nondestructive three-dimensional inspection of the internal structure of a sample to confirm the location, shape, and size of foreign matters found in tablets.

2. Elemental analysis of foreign matters by micro-XRF

Micro-XRF, which offers information about the elemental composition of materials, is widely used for analyzing inorganic substances such as metals. In addition, because decompression is not needed, this method is also suitable for analyzing samples that can not be vacuumed, such as hydrous samples and oils. The example described below shows the result of elemental analysis for the metal-like foreign matter in a tablet containing Fe, Cr, Mn, and Zn.

3. Analysis of foreign matters by FT-IR microscope and laser Raman microscope

FT-IR microscope and laser Raman microscope are primarily used to analyze foreign matters that appear to be organic materials, such as resin and fiber. We can obtain spectrums depending on chemical bindings; however, the chemical bindings that can be sensitively detected are different between the two methods. We have analyzed the fiber-like foreign matter found in a tablet and identified the base material of the foreign matter using FT-IR and further identified the coloring material using laser Raman microscope.